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NMR structure of the B0 isoform of the agrin G3 domain in its CA2+ bound state

Analyse NMR structure of the B0 isoform of the agrin G3 domain in its CA2+ bound state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Q56
Type: protein
Length: 195 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Agrin
UniProt: P31696
Pockets: 1 · best druggability 0.54

Structure

solution nmr · 1 distinct chain · 6% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Agrin	protein	195	6% helix, 35% strand	P31696

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.54	0.88	21	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1Q56 · NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state · the same entry in another collection · chain A against A, TM-score 1.00
P31696 · AlphaFold monomer V2.0 prediction for agrin (P31696) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31696
Elsewhere: RCSB PDB 1Q56 · PDBe 1Q56 · UniProt P31696

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