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Crystal structure of SARS-cov-2 mpro at 2.4 a resolution-11

Analyse Crystal structure of SARS-cov-2 mpro at 2.4 a resolution-11 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7VK7
Type: protein
Length: 599 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase
EC: 3.4.22.69
UniProt: P0DTC1
Pockets: 7 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.69)	protein	300	25% helix, 29% strand	P0DTC1
B	3C-like proteinase (EC 3.4.22.69)	protein	299	26% helix, 30% strand	P0DTC1

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	986	0.75	0.78	77	empty
2	750	0.70	0.76	94	empty
3	257	0.52	0.75	38	empty
4	146	0.45	0.76	20	empty
5	86	0.37	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 1123 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

7VK7 · Crystal Structure of SARS-CoV-2 Mpro at 2.4 A resolution-11 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTC1
Elsewhere: RCSB PDB 7VK7 · PDBe 7VK7 · UniProt P0DTC1

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