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Crystal structure of SARS-cov-2 mpro at 2.10 a resolution-2

Analyse Crystal structure of SARS-cov-2 mpro at 2.10 a resolution-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7VK3
Type: protein
Length: 599 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase
EC: 3.4.22.69
UniProt: P0DTC1
Pockets: 10 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.69)	protein	300	25% helix, 29% strand	P0DTC1
B	3C-like proteinase (EC 3.4.22.69)	protein	299	25% helix, 29% strand	P0DTC1

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	988	0.76	0.78	63	empty
2	398	0.62	0.77	49	empty
3	202	0.48	0.76	25	empty
4	87	0.43	0.79	19	empty
5	148	0.43	0.75	29	empty

Interfaces

1 interface between chains.

A–B · 1083 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

7VK3 · Crystal Structure of SARS-CoV-2 Mpro at 2.10 A resolution-2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTC1
Elsewhere: RCSB PDB 7VK3 · PDBe 7VK3 · UniProt P0DTC1

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