Research workbench
Structural insights into the membrane microdomain organization by spfh family proteins
Analyse Structural insights into the membrane microdomain organization by spfh family… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VHQ
- Type
- protein
- Length
- 2,076 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent zinc metalloprotease ftsh; Protein hflk; Modulator of ftsh protease hflc
- EC
- 3.4.24.-
- UniProt
- A0A376T6B9, A0A193M0W2, A0A3R1A7Q4
- Pockets
- 20 · best druggability 0.73
Structure
electron microscopy · 3 distinct chains · 53% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, e, f | ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-) | protein | 63 | 27% helix, 37% strand | A0A376T6B9 |
| E, F, U | Protein hflk | protein | 267 | 58% helix, 23% strand | A0A193M0W2 |
| G, H, I | Modulator of ftsh protease hflc | protein | 299 | 53% helix, 22% strand | A0A3R1A7Q4 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 903 | 0.73 | 0.78 | 86 | empty |
| 2 | 547 | 0.70 | 0.79 | 44 | empty |
| 3 | 62 | 0.70 | 0.96 | 24 | empty |
| 4 | 402 | 0.67 | 0.80 | 33 | empty |
| 5 | 509 | 0.63 | 0.75 | 55 | empty |
Interfaces
22 interfaces between chains.
- I–U · 4580 Ų buried · 34 hydrogen bonds · protein-protein
- E–H · 4478 Ų buried · 35 hydrogen bonds · protein-protein
- F–G · 4440 Ų buried · 28 hydrogen bonds · protein-protein
- E–G · 3967 Ų buried · 33 hydrogen bonds · protein-protein
- H–U · 2660 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7VHQ · Structural insights into the membrane microdomain organization by SPFH family proteins · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A376T6B9
- Every structure of UniProt A0A193M0W2
- Every structure of UniProt A0A3R1A7Q4
- Elsewhere: RCSB PDB 7VHQ · PDBe 7VHQ · UniProt A0A376T6B9 · UniProt A0A193M0W2 · UniProt A0A3R1A7Q4
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