Research workbench
Structural insights into the membrane microdomain organization by spfh family proteins
Analyse Structural insights into the membrane microdomain organization by spfh family… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VHP
- Type
- protein
- Length
- 8,304 residues
- Chains
- 48
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent zinc metalloprotease ftsh; Protein hflk; Modulator of ftsh protease hflc
- EC
- 3.4.24.-
- UniProt
- A0A024LAA6, C3SG32, V0YWD5
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 3 distinct chains · 53% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, e, f, W, Y, a, c, s, u, X, Z, b, d, t, v, J, K, L, M, T, V | ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-) | protein | 63 | 27% helix, 37% strand | A0A024LAA6 |
| E, F, U, g, i, q, h, j, r, N, O, S | Protein hflk | protein | 267 | 58% helix, 23% strand | C3SG32 |
| G, H, I, k, m, o, l, n, p, P, Q, R | Modulator of ftsh protease hflc | protein | 299 | 53% helix, 22% strand | V0YWD5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 944 | 0.77 | 0.80 | 76 | empty |
| 2 | 755 | 0.76 | 0.81 | 65 | empty |
| 3 | 866 | 0.74 | 0.78 | 71 | empty |
| 4 | 849 | 0.73 | 0.78 | 63 | empty |
| 5 | 830 | 0.73 | 0.78 | 70 | empty |
Interfaces
108 interfaces between chains.
- I–U · 4578 Ų buried · 34 hydrogen bonds · protein-protein
- R–S · 4576 Ų buried · 34 hydrogen bonds · protein-protein
- o–q · 4574 Ų buried · 34 hydrogen bonds · protein-protein
- p–r · 4560 Ų buried · 34 hydrogen bonds · protein-protein
- E–H · 4478 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
- 7VHP · Structural insights into the membrane microdomain organization by SPFH family proteins · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024LAA6
- Every structure of UniProt C3SG32
- Every structure of UniProt V0YWD5
- Elsewhere: RCSB PDB 7VHP · PDBe 7VHP · UniProt A0A024LAA6 · UniProt C3SG32 · UniProt V0YWD5
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