Research workbench
Cryo-EM structure of bovine ntcp complexed with YN69202FAB
Analyse Cryo-EM structure of bovine ntcp complexed with YN69202FAB in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VAE
- Type
- protein
- Length
- 736 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Solute carrier family 10 (SODIUM/BILE acid cotransporter family), member 1; Fab heavy…
- UniProt
- Q2KJ85
- Pockets
- 12 · best druggability 0.74
Structure
electron microscopy · 3 distinct chains · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 10 (SODIUM/BILE acid cotransporter family), member 1 | protein | 299 | 77% helix, 0% strand | Q2KJ85 |
| H | Fab heavy chain from antibody IgG clone number YN69202 | protein | 221 | 3% helix, 48% strand | — |
| L | Fab light chain from antibody IgG clone number YN69202 | protein | 216 | 5% helix, 42% strand | — |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 910 | 0.74 | 0.78 | 60 | empty |
| 2 | 391 | 0.58 | 0.75 | 51 | empty |
| 3 | 177 | 0.58 | 0.81 | 34 | empty |
| 4 | 163 | 0.57 | 0.81 | 17 | empty |
| 5 | 70 | 0.49 | 0.84 | 22 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1752 Ų buried · 7 hydrogen bonds · protein-protein
- A–H · 588 Ų buried · 9 hydrogen bonds · protein-protein
- A–L · 369 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7VAE · Cryo-EM structure of bovine NTCP complexed with YN69202Fab · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2KJ85
- Elsewhere: RCSB PDB 7VAE · PDBe 7VAE · UniProt Q2KJ85
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.