Research workbench
Crystal structure of the heptameric ECHSP60
Analyse Crystal structure of the heptameric ECHSP60 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V9R
- Type
- protein
- Length
- 3,635 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 60 kda chaperonin
- EC
- 5.6.1.7
- UniProt
- A0A097BVP4
- Pockets
- 20 · best druggability 0.71
Structure
x-ray diffraction · 7 distinct chains · 52% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 60 kda chaperonin (EC 5.6.1.7) | protein | 521 | 53% helix, 17% strand | A0A097BVP4 |
| B | 60 kda chaperonin (EC 5.6.1.7) | protein | 520 | 52% helix, 17% strand | A0A097BVP4 |
| C | 60 kda chaperonin (EC 5.6.1.7) | protein | 516 | 53% helix, 16% strand | A0A097BVP4 |
| D | 60 kda chaperonin (EC 5.6.1.7) | protein | 514 | 53% helix, 17% strand | A0A097BVP4 |
| E | 60 kda chaperonin (EC 5.6.1.7) | protein | 517 | 52% helix, 16% strand | A0A097BVP4 |
| F | 60 kda chaperonin (EC 5.6.1.7) | protein | 522 | 52% helix, 17% strand | A0A097BVP4 |
| G | 60 kda chaperonin (EC 5.6.1.7) | protein | 525 | 52% helix, 17% strand | A0A097BVP4 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 564 | 0.71 | 0.79 | 65 | empty |
| 2 | 497 | 0.70 | 0.80 | 57 | empty |
| 3 | 528 | 0.70 | 0.79 | 61 | empty |
| 4 | 533 | 0.70 | 0.79 | 60 | empty |
| 5 | 935 | 0.70 | 0.75 | 82 | empty |
Interfaces
7 interfaces between chains.
- F–G · 1368 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1358 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1351 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 1338 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1337 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7V9R · Crystal Structure of the heptameric EcHsp60 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A097BVP4
- Elsewhere: RCSB PDB 7V9R · PDBe 7V9R · UniProt A0A097BVP4
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