Research workbench

Campath-1G IGG2B rat monoclonal Fab

Analyse Campath-1G IGG2B rat monoclonal Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BFO
Type: protein
Length: 1,720 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Campath-1G antibody
Pockets: 20 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G	Campath-1G antibody	protein	214	6% helix, 50% strand	—
B, D, F, H	Campath-1G antibody	protein	216	7% helix, 48% strand	—

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	880	0.73	0.78	79	empty
2	626	0.70	0.78	63	empty
3	1080	0.69	0.74	86	empty
4	400	0.68	0.81	40	empty
5	394	0.66	0.79	51	empty

Interfaces

12 interfaces between chains.

A–B · 1942 Å² buried · 19 hydrogen bonds · protein-protein
E–F · 1940 Å² buried · 17 hydrogen bonds · protein-protein
C–D · 1919 Å² buried · 17 hydrogen bonds · protein-protein
G–H · 1909 Å² buried · 15 hydrogen bonds · protein-protein
F–G · 488 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

1BFO · Campath-1G IGG2B rat monoclonal Fab · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1BFO · PDBe 1BFO

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