Research workbench
Lccomt in complex with SAM
Analyse Lccomt in complex with SAM in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V6J
- Type
- protein
- Length
- 687 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lccomt
- Ligands
- SAM, NA
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lccomt | protein | 346 | 51% helix, 16% strand | — |
| B | Lccomt | protein | 341 | 49% helix, 17% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 921 | 0.78 | 0.80 | 64 | SAM |
| 2 | 870 | 0.78 | 0.81 | 63 | SAM |
| 3 | 185 | 0.57 | 0.80 | 19 | empty |
| 4 | 159 | 0.45 | 0.76 | 33 | empty |
| 5 | 131 | 0.41 | 0.75 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 4441 Ų buried · 48 hydrogen bonds · protein-protein
Compared structures
- 7V6J · LcCOMT in complex with SAM · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7V6J · PDBe 7V6J
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