Research workbench
Zikv NS3HELICASE in complex with ssrna and ATP-MN2+
Analyse Zikv NS3HELICASE in complex with ssrna and ATP-MN2+ in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V2Z
- Type
- protein + RNA
- Length
- 445 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Core protein; RNA (5'-R(*AP*GP*AP*UP*C)-3')
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13
- UniProt
- A0A1B0YUR2
- Ligands
- ATP, MN
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Core protein (EC 3.4.21.91, 3.6.1.15, 3.6.4.13) | protein | 440 | 33% helix, 19% strand | A0A1B0YUR2 |
| B | RNA (5'-R(*AP*GP*AP*UP*C)-3') | rna | 5 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.80 | 0.92 | 41 | empty |
| 2 | 470 | 0.72 | 0.82 | 68 | empty |
| 3 | 107 | 0.54 | 0.84 | 23 | MN, ATP |
| 4 | 101 | 0.39 | 0.76 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 866 Ų buried · 20 hydrogen bonds · protein-nucleic
Compared structures
- 7V2Z · ZIKV NS3helicase in complex with ssRNA and ATP-Mn2+ · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1B0YUR2
- Elsewhere: RCSB PDB 7V2Z · PDBe 7V2Z · UniProt A0A1B0YUR2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.