Research workbench
Human serine beta-lactamase-like protein lactb truncation variant
Analyse Human serine beta-lactamase-like protein lactb truncation variant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V21
- Type
- protein
- Length
- 1,505 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine beta-lactamase-like protein lactb, mitochondrial
- EC
- 3.4.-.-
- UniProt
- P83111
- Pockets
- 16 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Serine beta-lactamase-like protein lactb, mitochondrial (EC 3.4.-.-) | protein | 378 | 33% helix, 21% strand | P83111 |
| C | Serine beta-lactamase-like protein lactb, mitochondrial (EC 3.4.-.-) | protein | 374 | 32% helix, 21% strand | P83111 |
| D | Serine beta-lactamase-like protein lactb, mitochondrial (EC 3.4.-.-) | protein | 375 | 32% helix, 20% strand | P83111 |
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 334 | 0.83 | 0.93 | 34 | empty |
| 2 | 273 | 0.83 | 0.95 | 36 | empty |
| 3 | 746 | 0.65 | 0.74 | 64 | empty |
| 4 | 625 | 0.62 | 0.73 | 59 | empty |
| 5 | 226 | 0.58 | 0.79 | 35 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1103 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 1076 Ų buried · 19 hydrogen bonds · protein-protein
- B–D · 883 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 604 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 584 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7V21 · human Serine beta-lactamase-like protein LACTB truncation variant · the same entry in another collection · chain A against A, TM-score 1.00
- P83111 · AlphaFold monomer V2.0 prediction for serine beta-lactamase-like protein lactb… · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P83111
- Elsewhere: RCSB PDB 7V21 · PDBe 7V21 · UniProt P83111
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