Research workbench
Staphylococcus epidermidis RP62A CRISPR tall effector complex
Analyse Staphylococcus epidermidis RP62A CRISPR tall effector complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UZZ
- Type
- protein + RNA
- Length
- 2,410 residues
- Chains
- 11
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (37-mer); CRISPR system cms protein CSM2; CRISPR system cms protein CSM5; CRISPR…
- UniProt
- Q5HK90, Q5HK93, Q5HK91, Q5HK92, Q5HK89
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 9 distinct chains · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | RNA (37-mer) | rna | 30 | — | — |
| J | CRISPR system cms protein CSM2 | protein | 102 | 77% helix, 4% strand | Q5HK90 |
| I, K | CRISPR system cms protein CSM2 | protein | 117 | 74% helix, 5% strand | Q5HK90 |
| E | CRISPR system cms protein CSM5 | protein | 293 | 36% helix, 26% strand | Q5HK93 |
| D | CRISPR system cms endoribonuclease CSM3 | protein | 199 | 27% helix, 30% strand | Q5HK91 |
| C, A | CRISPR system cms endoribonuclease CSM3 | protein | 205 | 25% helix, 30% strand | Q5HK91 |
| B | CRISPR system cms endoribonuclease CSM3 | protein | 192 | 26% helix, 32% strand | Q5HK91 |
| H | CRISPR system cms protein CSM4 | protein | 296 | 24% helix, 23% strand | Q5HK92 |
| F | CRISPR system single-strand-specific deoxyribonuclease CAS10/CSM1 (subtype III-a) | protein | 654 | 55% helix, 13% strand | Q5HK89 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 846 | 0.82 | 0.84 | 88 | empty |
| 2 | 559 | 0.81 | 0.86 | 64 | empty |
| 3 | 790 | 0.79 | 0.83 | 49 | empty |
| 4 | 485 | 0.79 | 0.86 | 61 | empty |
| 5 | 147 | 0.78 | 0.95 | 24 | empty |
Interfaces
31 interfaces between chains.
- G–H · 1623 Ų buried · 35 hydrogen bonds · protein-nucleic
- H–F · 1582 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1465 Ų buried · 14 hydrogen bonds · protein-protein
- C–A · 1459 Ų buried · 8 hydrogen bonds · protein-protein
- D–C · 1450 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7UZZ · Staphylococcus epidermidis RP62a CRISPR tall effector complex · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5HK90
- Every structure of UniProt Q5HK93
- Every structure of UniProt Q5HK91
- Every structure of UniProt Q5HK92
- Every structure of UniProt Q5HK89
- Elsewhere: RCSB PDB 7UZZ · PDBe 7UZZ · UniProt Q5HK90 · UniProt Q5HK93 · UniProt Q5HK91 · UniProt Q5HK92 · UniProt Q5HK89
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