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Hexadecameric hub domain of camkii beta

Analyse Hexadecameric hub domain of camkii beta in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7URZ
Type: protein
Length: 508 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CALCIUM/CALMODULIN-dependent protein kinase type II subunit beta
EC: 2.7.11.17
UniProt: Q13554
Pockets: 8 · best druggability 0.75

Structure

x-ray diffraction · 4 distinct chains · 27% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
G	CALCIUM/CALMODULIN-dependent protein kinase type II subunit beta (EC 2.7.11.17)	protein	125	28% helix, 43% strand	Q13554
A	CALCIUM/CALMODULIN-dependent protein kinase type II subunit beta (EC 2.7.11.17)	protein	119	29% helix, 45% strand	Q13554
B	CALCIUM/CALMODULIN-dependent protein kinase type II subunit beta (EC 2.7.11.17)	protein	132	27% helix, 42% strand	Q13554
C	CALCIUM/CALMODULIN-dependent protein kinase type II subunit beta (EC 2.7.11.17)	protein	132	24% helix, 41% strand	Q13554

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.75	0.97	22	empty
2	175	0.67	0.86	31	empty
3	220	0.65	0.83	31	empty
4	268	0.60	0.79	22	empty
5	141	0.47	0.77	26	empty

Interfaces

3 interfaces between chains.

G–A · 598 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 597 Å² buried · 6 hydrogen bonds · protein-protein
G–C · 590 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

7URZ · Hexadecameric hub domain of CaMKII beta · the same entry in another collection · chain C against C, TM-score 1.00
Q13554 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II… · a predicted model of the same protein · chain G against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13554
Elsewhere: RCSB PDB 7URZ · PDBe 7URZ · UniProt Q13554

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