Research workbench
GEA2-ARF1 activation intermediate complex (composite structure)
Analyse GEA2-ARF1 activation intermediate complex (composite structure) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7URO
- Type
- protein
- Length
- 2,650 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GEA2 isoform 1; ARF1 isoform 1
- UniProt
- A0A8H8ULJ2, A0A6A5Q0M1
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 2 distinct chains · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | GEA2 isoform 1 | protein | 1160 | 69% helix, 0% strand | A0A8H8ULJ2 |
| B, D | ARF1 isoform 1 | protein | 165 | 35% helix, 19% strand | A0A6A5Q0M1 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 271 | 0.79 | 0.90 | 50 | empty |
| 2 | 546 | 0.74 | 0.81 | 60 | empty |
| 3 | 683 | 0.72 | 0.79 | 69 | empty |
| 4 | 76 | 0.72 | 0.95 | 20 | empty |
| 5 | 494 | 0.72 | 0.81 | 47 | empty |
Interfaces
3 interfaces between chains.
- A–C · 2366 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 1552 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1485 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7URO · Gea2-Arf1 activation intermediate complex (composite structure) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A8H8ULJ2
- Every structure of UniProt A0A6A5Q0M1
- Elsewhere: RCSB PDB 7URO · PDBe 7URO · UniProt A0A8H8ULJ2 · UniProt A0A6A5Q0M1
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