Research workbench
Crystal structure of a short chain dehydrogenase from mycobacterium avium 104
Analyse Crystal structure of a short chain dehydrogenase from mycobacterium avium 104 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ULH
- Type
- protein
- Length
- 1,984 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Short chain dehydrogenase
- UniProt
- A0A0H2ZRP4
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 6 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Short chain dehydrogenase | protein | 289 | 43% helix, 18% strand | A0A0H2ZRP4 |
| C | Short chain dehydrogenase | protein | 284 | 45% helix, 18% strand | A0A0H2ZRP4 |
| D | Short chain dehydrogenase | protein | 282 | 44% helix, 18% strand | A0A0H2ZRP4 |
| E | Short chain dehydrogenase | protein | 272 | 45% helix, 18% strand | A0A0H2ZRP4 |
| F | Short chain dehydrogenase | protein | 282 | 46% helix, 18% strand | A0A0H2ZRP4 |
| G | Short chain dehydrogenase | protein | 286 | 45% helix, 15% strand | A0A0H2ZRP4 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 833 | 0.73 | 0.78 | 116 | empty |
| 2 | 515 | 0.61 | 0.75 | 66 | empty |
| 3 | 493 | 0.61 | 0.75 | 58 | empty |
| 4 | 380 | 0.60 | 0.76 | 62 | empty |
| 5 | 319 | 0.59 | 0.77 | 52 | empty |
Interfaces
19 interfaces between chains.
- C–D · 4279 Ų buried · 71 hydrogen bonds · protein-protein
- A–B · 4264 Ų buried · 70 hydrogen bonds · protein-protein
- E–F · 4158 Ų buried · 64 hydrogen bonds · protein-protein
- A–D · 416 Ų buried · 2 hydrogen bonds · protein-protein
- B–E · 413 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7ULH · Crystal Structure of a Short chain dehydrogenase from Mycobacterium avium 104 · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H2ZRP4
- Elsewhere: RCSB PDB 7ULH · PDBe 7ULH · UniProt A0A0H2ZRP4
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