Research workbench

N-terminal domain deletion variant of eta

Analyse N-terminal domain deletion variant of eta in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7UJB
Type: protein
Length: 2,543 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DEAD/DEAH box RNA helicase
UniProt: Q5JF65
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 3 distinct chains · 47% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DEAD/DEAH box RNA helicase	protein	633	47% helix, 13% strand	Q5JF65
C	DEAD/DEAH box RNA helicase	protein	639	47% helix, 13% strand	Q5JF65
D	DEAD/DEAH box RNA helicase	protein	638	48% helix, 14% strand	Q5JF65

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	767	0.81	0.84	72	empty
2	831	0.81	0.84	90	empty
3	844	0.80	0.83	78	empty
4	690	0.80	0.84	77	empty
5	304	0.78	0.89	45	empty

Interfaces

3 interfaces between chains.

C–D · 1634 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 1585 Å² buried · 15 hydrogen bonds · protein-protein
A–D · 752 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7UJB · N-terminal domain deletion variant of Eta · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5JF65
Elsewhere: RCSB PDB 7UJB · PDBe 7UJB · UniProt Q5JF65

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