Research workbench
Human GATOR2 complex
Analyse Human GATOR2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UHY
- Type
- protein
- Length
- 3,657 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gator complex protein mios; Gator complex protein WDR24; Gator complex protein WDR59…
- UniProt
- Q9NXC5, Q96S15, Q6PJI9, Q96EE3, P55735
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 9 distinct chains · 23% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gator complex protein mios | protein | 771 | 31% helix, 23% strand | Q9NXC5 |
| B | Gator complex protein mios | protein | 761 | 32% helix, 23% strand | Q9NXC5 |
| C | Gator complex protein WDR24 | protein | 578 | 21% helix, 34% strand | Q96S15 |
| D | Gator complex protein WDR59 | protein | 288 | 43% helix, 13% strand | Q6PJI9 |
| E, F | Isoform B of nucleoporin SEH1 | protein | 319 | 2% helix, 52% strand | Q96EE3 |
| G | Isoform B of nucleoporin SEH1 | protein | 313 | 2% helix, 52% strand | Q96EE3 |
| H | Protein SEC13 homolog | protein | 285 | 3% helix, 55% strand | P55735 |
| I | Unknown | protein | 15 | 33% helix, 7% strand | — |
| J | Unknown | protein | 8 | 0% helix, 0% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 16 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 826 | 0.87 | 0.90 | 73 | empty |
| 2 | 839 | 0.84 | 0.87 | 57 | empty |
| 3 | 1136 | 0.84 | 0.85 | 76 | empty |
| 4 | 1111 | 0.84 | 0.85 | 103 | empty |
| 5 | 910 | 0.79 | 0.82 | 106 | empty |
Interfaces
17 interfaces between chains.
- A–C · 3443 Ų buried · 47 hydrogen bonds · protein-protein
- B–D · 3004 Ų buried · 40 hydrogen bonds · protein-protein
- C–G · 2924 Ų buried · 24 hydrogen bonds · protein-protein
- D–H · 2746 Ų buried · 17 hydrogen bonds · protein-protein
- A–E · 2558 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7UHY · Human GATOR2 complex · the same entry in another collection · chain J against J, TM-score 1.00
- P55735 · AlphaFold monomer V2.0 prediction for protein SEC13 homolog (P55735) · a predicted model of the same protein · chain H against A, TM-score 0.98
- Q96EE3 · AlphaFold monomer V2.0 prediction for nucleoporin SEH1 (Q96EE3) · a predicted model of the same protein · chain G against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NXC5
- Every structure of UniProt Q96S15
- Every structure of UniProt Q6PJI9
- Every structure of UniProt Q96EE3
- Every structure of UniProt P55735
- Elsewhere: RCSB PDB 7UHY · PDBe 7UHY · UniProt Q9NXC5 · UniProt Q96S15 · UniProt Q6PJI9 · UniProt Q96EE3 · UniProt P55735
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