Research workbench
Lxg-associated alpha-helical protein D2 (LAPD2)
Analyse Lxg-associated alpha-helical protein D2 (LAPD2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UH4
- Type
- protein
- Length
- 439 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lxg-associated alpha-helical protein D2
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 94% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Lxg-associated alpha-helical protein D2 | protein | 110 | 93% helix, 1% strand | — |
| B | Lxg-associated alpha-helical protein D2 | protein | 109 | 93% helix, 1% strand | — |
| D | Lxg-associated alpha-helical protein D2 | protein | 110 | 95% helix, 1% strand | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.59 | 0.87 | 16 | empty |
| 2 | 122 | 0.50 | 0.80 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–B · 877 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 844 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7UH4 · LXG-associated alpha-helical protein D2 (LapD2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7UH4 · PDBe 7UH4
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