Research workbench
Designed pentameric proton channel qqll
Analyse Designed pentameric proton channel qqll in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UDW
- Type
- protein
- Length
- 502 residues
- Chains
- 20
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- De novo designed pentameric proton channel qqll
- Pockets
- 13 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 91% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, E, F, G, H, I, K, M, N, P, R | De novo designed pentameric proton channel qqll | protein | 25 | 92% helix, 0% strand | — |
| B, Q, S, T | De novo designed pentameric proton channel qqll | protein | 26 | 88% helix, 0% strand | — |
| J, O | De novo designed pentameric proton channel qqll | protein | 24 | 92% helix, 0% strand | — |
| L | De novo designed pentameric proton channel qqll | protein | 25 | 92% helix, 0% strand | — |
Pockets
13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 875 | 0.83 | 0.84 | 61 | empty |
| 2 | 273 | 0.75 | 0.87 | 37 | empty |
| 3 | 141 | 0.74 | 0.91 | 25 | empty |
| 4 | 115 | 0.73 | 0.92 | 25 | empty |
| 5 | 127 | 0.73 | 0.91 | 25 | empty |
Interfaces
51 interfaces between chains.
- A–B · 641 Ų buried · 1 hydrogen bond · protein-protein
- L–T · 633 Ų buried · 1 hydrogen bond · protein-protein
- O–Q · 627 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 625 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 623 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7UDW · Designed pentameric proton channel QQLL · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7UDW · PDBe 7UDW
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