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Crystal structure of chimeric hemagglutinin CH4/3 in complex with broad protective antibody 31.A.83
Analyse Crystal structure of chimeric hemagglutinin CH4/3 in complex with broad… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7U8J
- Type
- protein
- Length
- 922 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin HA1 subunit; Hemagglutinin HA2 subunit; Antibody Fab light chain; Antibody…
- UniProt
- A0A3B1ELE4
- Pockets
- 11 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemagglutinin HA1 subunit | protein | 311 | 9% helix, 38% strand | — |
| B | Hemagglutinin HA2 subunit | protein | 173 | 51% helix, 15% strand | A0A3B1ELE4 |
| L | Antibody Fab light chain | protein | 213 | 4% helix, 46% strand | — |
| H | Antibody Fab heavy chain | protein | 225 | 5% helix, 47% strand | — |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 267 | 0.63 | 0.81 | 27 | empty |
| 2 | 52 | 0.61 | 0.93 | 17 | empty |
| 3 | 371 | 0.59 | 0.76 | 41 | empty |
| 4 | 258 | 0.47 | 0.73 | 31 | empty |
| 5 | 132 | 0.40 | 0.74 | 25 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2673 Ų buried · 33 hydrogen bonds · protein-protein
- L–H · 1896 Ų buried · 18 hydrogen bonds · protein-protein
- B–H · 613 Ų buried · 3 hydrogen bonds · protein-protein
- B–L · 161 Ų buried · 0 hydrogen bonds · protein-protein
- A–H · 77 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 7U8J · Crystal structure of chimeric hemagglutinin cH4/3 in complex with broad protective… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3B1ELE4
- Elsewhere: RCSB PDB 7U8J · PDBe 7U8J · UniProt A0A3B1ELE4
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