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Phenylalanine zipper mediates aps dimerization

Analyse Phenylalanine zipper mediates aps dimerization in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Q2H
Type: protein
Length: 188 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adaptor protein with pleckstrin homology and src homology 2 domains
UniProt: O14492
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 3 distinct chains · 84% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adaptor protein with pleckstrin homology and src homology 2 domains	protein	63	87% helix, 0% strand	O14492
B	Adaptor protein with pleckstrin homology and src homology 2 domains	protein	62	84% helix, 0% strand	O14492
C	Adaptor protein with pleckstrin homology and src homology 2 domains	protein	63	79% helix, 0% strand	O14492

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	394	0.57	0.74	43	empty
2	66	0.29	0.73	11	empty

Interfaces

3 interfaces between chains.

A–B · 2031 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 182 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 133 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1Q2H · Phenylalanine Zipper Mediates APS Dimerization · the same entry in another collection · chain A against A, TM-score 1.00
O14492 · AlphaFold monomer V2.0 prediction for SH2B adapter protein 2 (O14492) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14492
Elsewhere: RCSB PDB 1Q2H · PDBe 1Q2H · UniProt O14492

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