Research workbench

Ioma class antibody Fab ACS124

Analyse Ioma class antibody Fab ACS124 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7U0K
Type: protein
Length: 435 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ioma class antibody ACS124 light chain; Ioma class antibody ACS124 heavy chain
Pockets: 4 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Ioma class antibody ACS124 light chain	protein	210	8% helix, 50% strand	—
H	Ioma class antibody ACS124 heavy chain	protein	225	9% helix, 52% strand	—

Ligands and binding sites

NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · 2 copies · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	555	0.60	0.73	62	empty
2	87	0.48	0.82	19	NHE
3	64	0.37	0.78	20	empty
4	101	0.35	0.74	16	empty

Interfaces

1 interface between chains.

L–H · 2029 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7U0K · IOMA class antibody Fab ACS124 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7U0K · PDBe 7U0K

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