Research workbench

Ioma class antibody ACS101

Analyse Ioma class antibody ACS101 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7U04
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ioma class antibody ACS101 light chain; Ioma class antibody ACS101 heavy chain
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Ioma class antibody ACS101 light chain	protein	208	9% helix, 50% strand	—
H	Ioma class antibody ACS101 heavy chain	protein	228	8% helix, 50% strand	—

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	656	0.65	0.75	57	empty
2	117	0.46	0.79	24	empty
3	81	0.40	0.79	18	empty

Interfaces

1 interface between chains.

L–H · 1888 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 1 modified (disulfide, cyclization).

Compared structures

7U04 · IOMA class antibody ACS101 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7U04 · PDBe 7U04

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