Research workbench
Mouse importin alpha- phosphorylated SV40 cn peptide complex
Analyse Mouse importin alpha- phosphorylated SV40 cn peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Q1S
- Type
- protein
- Length
- 454 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Large T antigen; Importin alpha-2 subunit
- UniProt
- P03070
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Large T antigen | protein | 5 | 0% helix, 0% strand | P03070 |
| B | Large T antigen | protein | 15 | 0% helix, 0% strand | P03070 |
| C | Importin alpha-2 subunit | protein | 434 | 72% helix, 0% strand | P03070 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.44 | 0.83 | 13 | empty |
| 2 | 80 | 0.35 | 0.75 | 18 | empty |
Interfaces
2 interfaces between chains.
- B–C · 1016 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 535 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1Q1S · Mouse Importin alpha- phosphorylated SV40 CN peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03070
- Elsewhere: RCSB PDB 1Q1S · PDBe 1Q1S · UniProt P03070
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