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Structure of atopobium parvulum sufs C375S

Analyse Structure of atopobium parvulum sufs C375S in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7TLQ
Type: protein
Length: 825 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cysteine desulfurase
EC: 2.8.1.7
UniProt: C8W9P2
Ligands: PLP
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cysteine desulfurase (EC 2.8.1.7)	protein	413	45% helix, 17% strand	C8W9P2
B	Cysteine desulfurase (EC 2.8.1.7)	protein	412	45% helix, 17% strand	C8W9P2

Ligands and binding sites

PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	614	0.72	0.80	62	PLP
2	531	0.71	0.80	57	PLP
3	340	0.67	0.81	27	empty

Interfaces

1 interface between chains.

A–B · 3221 Å² buried · 60 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 cofactor (pyridoxal phosphate Schiff base).

Compared structures

7TLQ · Structure of Atopobium parvulum SufS C375S · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C8W9P2
Elsewhere: RCSB PDB 7TLQ · PDBe 7TLQ · UniProt C8W9P2

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