Research workbench
Anti-morphine antibody 9B1 complexed with morphine
Analyse Anti-morphine antibody 9B1 complexed with morphine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Q0Y
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab 9B1, light chain; Fab 9B1, heavy chain
- UniProt
- P01724, Q8VDC9
- Ligands
- MOI, SO4
- Pockets
- 3 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Fab 9B1, light chain | protein | 212 | 7% helix, 55% strand | P01724 |
| H | Fab 9B1, heavy chain | protein | 215 | 7% helix, 54% strand | Q8VDC9 |
Ligands and binding sites
- MOI · (7r,7as,12bs)-3-methyl-2,3,4,4A,7,7A-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol · ligand · chains L, H
- SO4 · Sulfate ion · ion · 2 copies · chains L, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.46 | 0.75 | 27 | empty |
| 2 | 93 | 0.35 | 0.74 | 18 | empty |
| 3 | 72 | 0.32 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- L–H · 1883 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01724
- Every structure of UniProt Q8VDC9
- Elsewhere: RCSB PDB 1Q0Y · PDBe 1Q0Y · UniProt P01724 · UniProt Q8VDC9
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