Research workbench
L. monocytogenes GS(14)-Q-glnr peptide
Analyse L. monocytogenes GS(14)-Q-glnr peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TF9
- Type
- protein
- Length
- 6,272 residues
- Chains
- 28
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine synthetase; C-tail peptide of glutamine synthetase repressor
- EC
- 6.3.1.2
- UniProt
- A0A5D5GA79, A0A807UZD6
- Ligands
- GLN, MG
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, F, G, H, I, N, O, P, Q, R, S, T | Glutamine synthetase (EC 6.3.1.2) | protein | 443 | 40% helix, 22% strand | A0A5D5GA79 |
| D, E, J, K, L, M, U, V, W, X, Y, Z, a, b | C-tail peptide of glutamine synthetase repressor | protein | 5 | 0% helix, 0% strand | A0A807UZD6 |
Ligands and binding sites
- GLN · Glutamine · ligand · 14 copies · chains A, N, B, C, Q, F, G, H, S, I, R, O, P, T
- MG · Magnesium ion · metal · 28 copies · chains A, N, B, C, Q, F, G, H, S, I, R, O, P, T
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 342 | 0.80 | 0.90 | 49 | MG, GLN |
| 2 | 834 | 0.79 | 0.82 | 74 | empty |
| 3 | 344 | 0.79 | 0.89 | 54 | MG, GLN |
| 4 | 376 | 0.79 | 0.88 | 52 | MG, GLN |
| 5 | 337 | 0.79 | 0.89 | 48 | MG, GLN |
Interfaces
63 interfaces between chains.
- P–T · 2147 Ų buried · 32 hydrogen bonds · protein-protein
- I–O · 2141 Ų buried · 32 hydrogen bonds · protein-protein
- B–S · 2099 Ų buried · 31 hydrogen bonds · protein-protein
- N–R · 2095 Ų buried · 31 hydrogen bonds · protein-protein
- C–H · 2095 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7TF9 · L. monocytogenes GS(14)-Q-GlnR peptide · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A5D5GA79
- Every structure of UniProt A0A807UZD6
- Elsewhere: RCSB PDB 7TF9 · PDBe 7TF9 · UniProt A0A5D5GA79 · UniProt A0A807UZD6
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