Research workbench
Crystal structure of FAB2 anti-GLUN2B antibody
Analyse Crystal structure of FAB2 anti-GLUN2B antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TE4
- Type
- protein
- Length
- 824 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FAB2 anti-GLUN2B antibody, light chain; Fab anti-GLUN2B antibody, heavy chain
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | FAB2 anti-GLUN2B antibody, light chain | protein | 206 | 6% helix, 51% strand | — |
| H | Fab anti-GLUN2B antibody, heavy chain | protein | 210 | 8% helix, 53% strand | — |
| A | FAB2 anti-GLUN2B antibody, light chain | protein | 207 | 6% helix, 52% strand | — |
| B | Fab anti-GLUN2B antibody, heavy chain | protein | 201 | 3% helix, 53% strand | — |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 822 | 0.76 | 0.80 | 88 | empty |
| 2 | 51 | 0.57 | 0.91 | 20 | empty |
| 3 | 50 | 0.53 | 0.89 | 21 | empty |
| 4 | 106 | 0.48 | 0.81 | 24 | empty |
| 5 | 119 | 0.47 | 0.79 | 23 | empty |
Interfaces
4 interfaces between chains.
- L–H · 1726 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1651 Ų buried · 10 hydrogen bonds · protein-protein
- L–A · 331 Ų buried · 1 hydrogen bond · protein-protein
- H–A · 34 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 7TE4 · Crystal structure of Fab2 anti-GluN2B antibody · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7TE4 · PDBe 7TE4
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