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Structure of FOXP3-DNA complex

Analyse Structure of FOXP3-DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7TDX
Type: protein + DNA
Length: 118 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*AP*CP*TP*C)-3'); DNA…
UniProt: Q53Z59
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 3 distinct chains · 43% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	DNA (5'-D(APAPAPTPTPTPGPTPTPTPAPCPTPC)-3')	dna	14	—	—
C	DNA (5'-D(PGPAPGPTPAPAPAPCPAPAPAPTPTPT)-3')	dna	14	—	—
A	Forkhead box P3	protein	90	43% helix, 14% strand	Q53Z59

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.52	0.85	19	empty
2	100	0.38	0.77	18	empty

Interfaces

3 interfaces between chains.

B–C · 594 Å² buried · 46 hydrogen bonds · nucleic-nucleic
C–A · 446 Å² buried · 10 hydrogen bonds · protein-nucleic
B–A · 427 Å² buried · 5 hydrogen bonds · protein-nucleic

Compared structures

7TDX · Structure of FOXP3-DNA complex · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53Z59
Elsewhere: RCSB PDB 7TDX · PDBe 7TDX · UniProt Q53Z59

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