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G-925 bound to the SMARCA4 (BRG1) bromodomain

Analyse G-925 bound to the SMARCA4 (BRG1) bromodomain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7TAB
Type: protein
Length: 123 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform 4 of transcription activator BRG1
EC: 3.6.4.-
Ligands: GGU
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoform 4 of transcription activator BRG1 (EC 3.6.4.-)	protein	123	63% helix, 2% strand	—

Ligands and binding sites

GGU · 2-(6-amino-5-phenylpyridazin-3-yl)phenol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.49	0.84	16	GGU

Compared structures

7TAB · G-925 bound to the SMARCA4 (BRG1) Bromodomain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7TAB · PDBe 7TAB

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