Research workbench
Structure of antibody 3G12 bound to respiratory syncytial virus G central conserved domain mutant S177Q
Analyse Structure of antibody 3G12 bound to respiratory syncytial virus G central… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7T8W
- Type
- protein
- Length
- 471 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3G12 Fab light chain; 3G12 Fab heavy chain; Mature secreted glycoprotein G
- UniProt
- P03423
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | 3G12 Fab light chain | protein | 212 | 7% helix, 51% strand | — |
| H | 3G12 Fab heavy chain | protein | 229 | 8% helix, 52% strand | — |
| D | Mature secreted glycoprotein G | protein | 30 | 23% helix, 10% strand | P03423 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 447 | 0.57 | 0.73 | 56 | empty |
| 2 | 64 | 0.43 | 0.82 | 22 | empty |
| 3 | 53 | 0.43 | 0.83 | 18 | empty |
| 4 | 68 | 0.30 | 0.74 | 18 | empty |
Interfaces
3 interfaces between chains.
- L–H · 2139 Ų buried · 13 hydrogen bonds · protein-protein
- H–D · 708 Ų buried · 10 hydrogen bonds · protein-protein
- L–D · 256 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7T8W · Structure of antibody 3G12 bound to Respiratory Syncytial Virus G central conserved… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03423
- Elsewhere: RCSB PDB 7T8W · PDBe 7T8W · UniProt P03423
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.