Research workbench
Structure of active janus kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Analyse Structure of active janus kinase (JAK) dimer complexed with cytokine receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7T6F
- Type
- protein
- Length
- 2,164 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- B1ASP2, Q8CGK5
- Ligands
- ADN, ADP
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 1045 | — | B1ASP2 |
| C, D | — | protein | 37 | — | Q8CGK5 |
Ligands and binding sites
- ADN · Adenosine · ligand · 2 copies · chains A, B
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7T6F · Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8CGK5 · AlphaFold monomer V2.0 prediction for interferon lambda receptor 1 (Q8CGK5) · a predicted model of the same protein · chain C against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1ASP2
- Every structure of UniProt Q8CGK5
- Elsewhere: RCSB PDB 7T6F · PDBe 7T6F · UniProt B1ASP2 · UniProt Q8CGK5
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