Research workbench

GPC2 hep CT3 complex

Analyse GPC2 hep CT3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7T62
Type: protein
Length: 993 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glypican-2; CT3
UniProt: Q8N158
Pockets: 9 · best druggability 0.56

Structure

electron microscopy · 2 distinct chains · 33% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glypican-2	protein	561	55% helix, 4% strand	Q8N158
B	CT3	protein	432	5% helix, 52% strand	—

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	370	0.56	0.75	54	empty
2	61	0.56	0.89	15	empty
3	139	0.48	0.78	25	empty
4	114	0.45	0.78	19	empty
5	155	0.44	0.76	27	empty

Modifications

Observed in the structure: 11 disulfide (disulfide).

Compared structures

7T62 · GPC2 HEP CT3 complex · the same entry in another collection · chain B against B, TM-score 1.00
Q8N158 · AlphaFold monomer V2.0 prediction for glypican-2 (Q8N158) · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N158
Elsewhere: RCSB PDB 7T62 · PDBe 7T62 · UniProt Q8N158

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.