Research workbench
Inactivated state of 2-apb and cbd-bound wildtype rat TRPV2 in nanodiscs
Analyse Inactivated state of 2-apb and cbd-bound wildtype rat TRPV2 in nanodiscs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7T38
- Type
- protein
- Length
- 2,432 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 2
- UniProt
- Q9WUD2
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 54% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily V member 2 | protein | 608 | 54% helix, 6% strand | Q9WUD2 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1134 | 0.87 | 0.87 | 88 | empty |
| 2 | 357 | 0.78 | 0.88 | 29 | empty |
| 3 | 363 | 0.78 | 0.87 | 31 | empty |
| 4 | 352 | 0.77 | 0.87 | 31 | empty |
| 5 | 368 | 0.77 | 0.87 | 30 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2837 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 2836 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 2834 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 2822 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 21 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7T38 · Inactivated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WUD2 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WUD2
- Elsewhere: RCSB PDB 7T38 · PDBe 7T38 · UniProt Q9WUD2
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