Research workbench
GET3 bound to ADP and the transmembrane domain of the tail-anchored protein BOS1
Analyse GET3 bound to ADP and the transmembrane domain of the tail-anchored protein BOS1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SQ0
- Type
- protein
- Length
- 630 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATPase ASNA1 homolog; Tmd of the tail-anchored protein BOS1
- EC
- 3.6.-.-
- UniProt
- A8B3G9
- Ligands
- ADP, MG, ZN
- Pockets
- 7 · best druggability 0.89
Structure
electron microscopy · 3 distinct chains · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATPase ASNA1 homolog (EC 3.6.-.-) | protein | 306 | 51% helix, 13% strand | A8B3G9 |
| B | ATPase ASNA1 homolog (EC 3.6.-.-) | protein | 302 | 50% helix, 14% strand | A8B3G9 |
| C | Tmd of the tail-anchored protein BOS1 | protein | 22 | 82% helix, 0% strand | — |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- ZN · Zinc ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1185 | 0.89 | 0.91 | 134 | ADP, MG |
| 2 | 901 | 0.85 | 0.86 | 110 | empty |
| 3 | 73 | 0.70 | 0.95 | 22 | empty |
| 4 | 95 | 0.60 | 0.87 | 21 | empty |
| 5 | 89 | 0.57 | 0.86 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1961 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 358 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 236 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7SQ0 · Get3 bound to ADP and the transmembrane domain of the tail-anchored protein Bos1 · the same entry in another collection · chain A against A, TM-score 1.00
- A8B3G9 · AlphaFold monomer V2.0 prediction for ATPase ASNA1 homolog (A8B3G9) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8B3G9
- Elsewhere: RCSB PDB 7SQ0 · PDBe 7SQ0 · UniProt A8B3G9
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