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Lam domain of human LARP1 in complex with aaaa RNA

Analyse Lam domain of human LARP1 in complex with aaaa RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7SOS
Type: protein + RNA
Length: 92 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform 2 of la-related protein 1; RNA (5'-R(*AP*AP*AP*A)-3')
Ligands: K
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 53% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoform 2 of la-related protein 1	protein	88	53% helix, 11% strand	—
B	RNA (5'-R(APAPAPA)-3')	rna	4	—	—

Ligands and binding sites

K · Potassium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.30	0.77	9	empty

Interfaces

1 interface between chains.

A–B · 449 Å² buried · 12 hydrogen bonds · protein-nucleic

Compared structures

7SOS · LaM domain of human LARP1 in complex with AAAA RNA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7SOS · PDBe 7SOS

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