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Structure of human SARS-cov-2 neutralizing antibody C1C-A3 Fab

Analyse Structure of human SARS-cov-2 neutralizing antibody C1C-A3 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7SN1
Type: protein
Length: 430 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neutralizing antibody C1C-A3 Fab heavy chain; Neutralizing antibody C1C-A3 Fab light chain
Pockets: 4 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Neutralizing antibody C1C-A3 Fab heavy chain	protein	216	9% helix, 54% strand	—
L	Neutralizing antibody C1C-A3 Fab light chain	protein	214	5% helix, 52% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	620	0.63	0.74	63	empty
2	58	0.45	0.84	25	empty
3	133	0.45	0.77	25	empty
4	69	0.29	0.73	16	empty

Interfaces

1 interface between chains.

H–L · 1784 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7SN1 · Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7SN1 · PDBe 7SN1

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