Research workbench
Crystal structure of consomatin-RO1 <STRUCTURE_DETAILS=CONSOMATIN-RO1, a cone snail venom sstl mimetic
Analyse Crystal structure of consomatin-RO1 <STRUCTURE_DETAILS=CONSOMATIN-RO1, a cone… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SMU
- Type
- protein
- Length
- 78 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Consomatin-RO1
- Ligands
- V1J
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D, E, C, B, F, A | Consomatin-RO1 | protein | 13 | 0% helix, 62% strand | — |
Ligands and binding sites
- V1J · 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45-pentadecaoxaoctatetracontane-1,48-diol · ligand · chains D, E, C, B, F, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.49 | 0.74 | 29 | V1J |
Interfaces
6 interfaces between chains.
- C–B · 337 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 313 Ų buried · 7 hydrogen bonds · protein-protein
- D–C · 279 Ų buried · 6 hydrogen bonds · protein-protein
- B–A · 261 Ų buried · 7 hydrogen bonds · protein-protein
- D–E · 233 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified, 6 d-amino, 6 disulfide (D-amino acid, disulfide, carboxylation, hydroxylation).
Compared structures
- 7SMU · Crystal Structure of Consomatin-Ro1 <structure_details=Consomatin-Ro1, a cone snail venom… · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7SMU · PDBe 7SMU
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.