Research workbench

Protease inhibitors variant, cti-homolog pacifastin

Analyse Protease inhibitors variant, cti-homolog pacifastin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7SLT
Type: protein
Length: 131 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protease inhibitor lcmi-II
UniProt: P80060

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, D	Protease inhibitor lcmi-II	protein	33	0% helix, 48% strand	P80060
B	Protease inhibitor lcmi-II	protein	32	0% helix, 50% strand	P80060

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains A, D, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

A–C · 946 Å² buried · 26 hydrogen bonds · protein-protein
B–D · 930 Å² buried · 25 hydrogen bonds · protein-protein
A–B · 21 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

7SLT · Protease inhibitors variant, CTI-homolog pacifastin · the same entry in another collection · chain A against A, TM-score 1.00
P80060 · AlphaFold monomer V2.0 prediction for protease inhibitors (P80060) · a predicted model of the same protein · chain B against A, TM-score 0.48

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P80060
Elsewhere: RCSB PDB 7SLT · PDBe 7SLT · UniProt P80060

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