Research workbench
Cryo-EM structure of NSE5/6 heterodimer
Analyse Cryo-EM structure of NSE5/6 heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SDE
- Type
- protein
- Length
- 726 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural maintenance of chromosome element 5; Ubiquitin-like protein SMT3,DNA…
- UniProt
- Q03718, P40026
- Pockets
- 14 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 51% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-structural maintenance of chromosome element 5 | protein | 488 | 52% helix, 1% strand | Q03718 |
| B | Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera | protein | 238 | 50% helix, 1% strand | P40026 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 785 | 0.80 | 0.83 | 69 | empty |
| 2 | 152 | 0.78 | 0.94 | 27 | empty |
| 3 | 55 | 0.73 | 0.99 | 13 | empty |
| 4 | 54 | 0.58 | 0.90 | 15 | empty |
| 5 | 110 | 0.53 | 0.83 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1930 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7SDE · Cryo-EM structure of Nse5/6 heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- Q03718 · AlphaFold monomer V2.0 prediction for non-structural maintenance of chromosome element 5… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P40026 · AlphaFold monomer V2.0 prediction for DNA repair protein KRE29 (P40026) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03718
- Every structure of UniProt P40026
- Elsewhere: RCSB PDB 7SDE · PDBe 7SDE · UniProt Q03718 · UniProt P40026
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.