Research workbench
Human glutaminase C (Y466W) with L-gln, closed conformation
Analyse Human glutaminase C (Y466W) with L-gln, closed conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SBN
- Type
- protein
- Length
- 1,627 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 3 of glutaminase kidney isoform, mitochondrial
- EC
- 3.5.1.2
- UniProt
- O94925
- Ligands
- GLN
- Pockets
- 11 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 409 | 49% helix, 11% strand | O94925 |
| B | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 405 | 50% helix, 12% strand | O94925 |
| C | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 407 | 49% helix, 12% strand | O94925 |
| D | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 406 | 48% helix, 11% strand | O94925 |
Ligands and binding sites
- GLN · Glutamine · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 965 | 0.80 | 0.82 | 118 | GLN |
| 2 | 1038 | 0.80 | 0.81 | 122 | GLN |
| 3 | 377 | 0.69 | 0.82 | 47 | empty |
| 4 | 420 | 0.69 | 0.81 | 48 | empty |
| 5 | 51 | 0.59 | 0.91 | 20 | empty |
Interfaces
4 interfaces between chains.
- A–C · 1816 Ų buried · 28 hydrogen bonds · protein-protein
- B–D · 1718 Ų buried · 27 hydrogen bonds · protein-protein
- C–D · 606 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 523 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7SBN · Human glutaminase C (Y466W) with L-Gln, closed conformation · the same entry in another collection · chain B against B, TM-score 1.00
- O94925 · AlphaFold monomer V2.0 prediction for glutaminase kidney isoform, mitochondrial (O94925) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94925
- Elsewhere: RCSB PDB 7SBN · PDBe 7SBN · UniProt O94925
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