Research workbench
Structure of type I-D cascade bound to a ssrna target
Analyse Structure of type I-D cascade bound to a ssrna target in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SBB
- Type
- protein + RNA
- Length
- 3,511 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CAS7D; CAS5D; CAS10D; CAS11D; Ssrna target; Crrna
- UniProt
- Q6ZEI6, Q6ZEI5, Q6ZEI7
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 6 distinct chains · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | CAS7D | protein | 320 | 34% helix, 29% strand | Q6ZEI6 |
| H | CAS5D | protein | 223 | 10% helix, 47% strand | Q6ZEI5 |
| I | CAS10D | protein | 680 | 62% helix, 7% strand | Q6ZEI7 |
| J, K | CAS11D | protein | 146 | 72% helix, 0% strand | Q6ZEI7 |
| X | Ssrna target | rna | 33 | — | — |
| Z | Crrna | rna | 43 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 576 | 0.85 | 0.90 | 72 | empty |
| 2 | 614 | 0.84 | 0.89 | 49 | empty |
| 3 | 443 | 0.83 | 0.91 | 55 | empty |
| 4 | 159 | 0.81 | 0.97 | 46 | empty |
| 5 | 108 | 0.78 | 0.98 | 30 | empty |
Interfaces
45 interfaces between chains.
- F–G · 2507 Ų buried · 47 hydrogen bonds · protein-protein
- D–E · 2383 Ų buried · 48 hydrogen bonds · protein-protein
- B–C · 2337 Ų buried · 59 hydrogen bonds · protein-protein
- C–D · 2322 Ų buried · 53 hydrogen bonds · protein-protein
- E–F · 2299 Ų buried · 45 hydrogen bonds · protein-protein
Compared structures
- 7SBB · Structure of type I-D Cascade bound to a ssRNA target · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6ZEI6
- Every structure of UniProt Q6ZEI5
- Every structure of UniProt Q6ZEI7
- Elsewhere: RCSB PDB 7SBB · PDBe 7SBB · UniProt Q6ZEI6 · UniProt Q6ZEI5 · UniProt Q6ZEI7
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