Research workbench
Structure of anti-lasv Fab 25.10C with fnqi mutation
Analyse Structure of anti-lasv Fab 25.10C with fnqi mutation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7S8G
- Type
- protein
- Length
- 838 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 25.10C-fnqi Fab heavy chain; 25.10C-fnqi Fab light chain
- Pockets
- 7 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | 25.10C-fnqi Fab heavy chain | protein | 212 | 5% helix, 54% strand | — |
| L, l | 25.10C-fnqi Fab light chain | protein | 209 | 7% helix, 50% strand | — |
| h | 25.10C-fnqi Fab heavy chain | protein | 208 | 8% helix, 51% strand | — |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 621 | 0.74 | 0.81 | 66 | empty |
| 2 | 309 | 0.70 | 0.84 | 37 | empty |
| 3 | 252 | 0.63 | 0.81 | 35 | empty |
| 4 | 302 | 0.58 | 0.77 | 44 | empty |
| 5 | 350 | 0.57 | 0.76 | 46 | empty |
Interfaces
6 interfaces between chains.
- H–L · 1088 Ų buried · 15 hydrogen bonds · protein-protein
- h–l · 962 Ų buried · 13 hydrogen bonds · protein-protein
- H–l · 944 Ų buried · 4 hydrogen bonds · protein-protein
- L–h · 883 Ų buried · 4 hydrogen bonds · protein-protein
- H–h · 702 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 7S8G · Structure of anti-LASV Fab 25.10C with FNQI mutation · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7S8G · PDBe 7S8G
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.