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Crystal structure of human chemokine CCL8

Analyse Crystal structure of human chemokine CCL8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7S5A
Type: protein
Length: 149 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-C motif chemokine 8
UniProt: P80075

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	C-C motif chemokine 8	protein	73	23% helix, 27% strand	P80075
B	C-C motif chemokine 8	protein	76	22% helix, 26% strand	P80075

Interfaces

1 interface between chains.

A–B · 827 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7S5A · Crystal structure of human chemokine CCL8 · the same entry in another collection · chain B against B, TM-score 1.00
P80075 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 8 (P80075) · a predicted model of the same protein · chain B against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P80075
Elsewhere: RCSB PDB 7S5A · PDBe 7S5A · UniProt P80075

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