Research workbench
Antibody to campath-1H humanized Fab
Analyse Antibody to campath-1H humanized Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BEY
- Type
- protein
- Length
- 424 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Campath-1H antibody
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Campath-1H antibody | protein | 214 | 0% helix, 37% strand | — |
| H | Campath-1H antibody | protein | 210 | 1% helix, 36% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 627 | 0.63 | 0.74 | 69 | empty |
| 2 | 54 | 0.46 | 0.85 | 22 | empty |
| 3 | 97 | 0.33 | 0.73 | 19 | empty |
| 4 | 59 | 0.27 | 0.73 | 12 | empty |
| 5 | 51 | 0.23 | 0.72 | 17 | empty |
Interfaces
1 interface between chains.
- L–H · 1692 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1BEY · Antibody to campath-1H humanized Fab · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1BEY · PDBe 1BEY
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