Research workbench
Cryo-EM structure of KIFBP:KIF15
Analyse Cryo-EM structure of KIFBP:KIF15 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RYP
- Type
- protein
- Length
- 725 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein KIF15; Kif-binding protein
- UniProt
- Q9NS87, Q96EK5
- Pockets
- 15 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 55% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinesin-like protein KIF15 | protein | 333 | 30% helix, 22% strand | Q9NS87 |
| B | Kif-binding protein | protein | 392 | 76% helix, 0% strand | Q96EK5 |
Pockets
15 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 880 | 0.86 | 0.88 | 108 | empty |
| 2 | 763 | 0.78 | 0.82 | 72 | empty |
| 3 | 728 | 0.75 | 0.80 | 89 | empty |
| 4 | 597 | 0.74 | 0.81 | 53 | empty |
| 5 | 178 | 0.70 | 0.88 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 856 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7RYP · Cryo-EM structure of KIFBP:KIF15 · the same entry in another collection · chain A against A, TM-score 1.00
- Q96EK5 · AlphaFold monomer V2.0 prediction for kif-binding protein (Q96EK5) · a predicted model of the same protein · chain B against A, TM-score 0.83
- Q9NS87 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF15 (Q9NS87) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NS87
- Every structure of UniProt Q96EK5
- Elsewhere: RCSB PDB 7RYP · PDBe 7RYP · UniProt Q9NS87 · UniProt Q96EK5
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