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Structure of plasmepsin X (PM10, pmx) from plasmodium falciparum 3D7

Analyse Structure of plasmepsin X (PM10, pmx) from plasmodium falciparum 3D7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RY7
Type: protein
Length: 433 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasmepsin X
EC: 3.4.23.1
UniProt: Q8IAS0
Ligands: NAG
Pockets: 3 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plasmepsin X (EC 3.4.23.1)	protein	433	18% helix, 35% strand	Q8IAS0

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	442	0.67	0.79	69	empty
2	236	0.54	0.77	33	empty
3	53	0.34	0.78	17	empty

Modifications

Observed in the structure: 5 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

7RY7 · Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IAS0
Elsewhere: RCSB PDB 7RY7 · PDBe 7RY7 · UniProt Q8IAS0

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