Research workbench

Crystal structure of junctophilin-2

Analyse Crystal structure of junctophilin-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RXE
Type: protein
Length: 312 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Junctophilin-2 N-terminal fragment
UniProt: Q9BR39
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Junctophilin-2 N-terminal fragment	protein	312	25% helix, 47% strand	Q9BR39

Ligands and binding sites

IPA · Isopropyl alcohol · additive · 3 copies · chains A
FLC · Citrate anion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.39	0.78	15	empty
2	51	0.27	0.74	12	empty

Compared structures

7RXE · Crystal structure of junctophilin-2 · the same entry in another collection · chain A against A, TM-score 1.00
Q9BR39 · AlphaFold monomer V2.0 prediction for junctophilin-2 (Q9BR39) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BR39
Elsewhere: RCSB PDB 7RXE · PDBe 7RXE · UniProt Q9BR39

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.