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Cryo-EM structure of the HIV-1 restriction factor human SERINC3

Analyse Cryo-EM structure of the HIV-1 restriction factor human SERINC3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RU6
Type: protein
Length: 331 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine incorporator 3; Sia
UniProt: Q13530
Pockets: 5 · best druggability 0.53

Structure

electron microscopy · 2 distinct chains · 78% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serine incorporator 3	protein	315	81% helix, 1% strand	Q13530
L	Sia	protein	16	19% helix, 38% strand	—

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	110	0.53	0.83	19	empty
2	168	0.53	0.78	24	empty
3	70	0.34	0.75	19	empty
4	55	0.32	0.76	10	empty
5	55	0.29	0.74	16	empty

Interfaces

1 interface between chains.

A–L · 695 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

7RU6 · Cryo-EM structure of the HIV-1 restriction factor human SERINC3 · the same entry in another collection · chain A against A, TM-score 1.00
Q13530 · AlphaFold monomer V2.0 prediction for serine incorporator 3 (Q13530) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13530
Elsewhere: RCSB PDB 7RU6 · PDBe 7RU6 · UniProt Q13530

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