Research workbench
Crystal structure of the RHSP2 C-terminal toxin domain in complex with its immunity protein, RHSI2
Analyse Crystal structure of the RHSP2 C-terminal toxin domain in complex with its… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RT7
- Type
- protein
- Length
- 1,718 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RHSP2; RHSI2
- UniProt
- A0A0H2Z8A2, A0A367GXM0
- Pockets
- 20 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 25% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E, G, K | RHSP2 | protein | 143 | 30% helix, 29% strand | A0A0H2Z8A2 |
| D, C, F, H, J, L | RHSI2 | protein | 144 | 22% helix, 35% strand | A0A367GXM0 |
| I | RHSP2 | protein | 139 | 24% helix, 29% strand | A0A0H2Z8A2 |
Ligands and binding sites
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 3 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 384 | 0.59 | 0.76 | 33 | empty |
| 2 | 303 | 0.58 | 0.77 | 37 | empty |
| 3 | 393 | 0.57 | 0.75 | 45 | empty |
| 4 | 191 | 0.54 | 0.78 | 32 | empty |
| 5 | 290 | 0.53 | 0.75 | 33 | empty |
Interfaces
14 interfaces between chains.
- A–D · 1243 Ų buried · 28 hydrogen bonds · protein-protein
- I–J · 1225 Ų buried · 29 hydrogen bonds · protein-protein
- B–C · 1216 Ų buried · 26 hydrogen bonds · protein-protein
- G–H · 1197 Ų buried · 28 hydrogen bonds · protein-protein
- E–F · 1183 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 7RT7 · Crystal structure of the RhsP2 C-terminal toxin domain in complex with its immunity… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H2Z8A2
- Every structure of UniProt A0A367GXM0
- Elsewhere: RCSB PDB 7RT7 · PDBe 7RT7 · UniProt A0A0H2Z8A2 · UniProt A0A367GXM0
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